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This is the preview of membership written content, log in by using an establishment to examine entry. Obtain this short articleThe current in vitro findings demonstrate the cytotoxicity of MAM-2201 on human primary neurons (hNLCs) and astrocytes cell line (D384), and assist using these mobile models as species-particular in vitro equipment ideal to
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Opposition binding experiments done in CHO cell membranes transfected with human CB1 or CB2 receptors revealed affinity values during the lower nanomolar range for both of those the tested compounds AM-2201 and MAM-2201 (Desk 1). Similar outcomes had been received assessing affinity values of The 2 synthetic cannabinoids in mouse tissues suggesting